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KMID : 1098420050130040161
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Korean Journal of Medicinal Crop Science
2005 Volume.13 No. 4 p.161 ~ p.170
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Immuno-regulatory Activities of Various Fractions from Ehpedrae Sinica STAPF, Rubus Coreanus Miq. and Angelica gigas Nakai Extracts with Ultrasonification
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Kim Jung-Hwa
Kim Dae-Ho
You Jin-Hyun
Kim Cheol-Hee
Kwon Min-Cheol
Seong Nak-Sul
Lee Seung-Eun
Lee Hyeon-Yong
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Abstract
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This study was performed to examine immuno-regulatory activities of Ehpedrae Sinica STAPF, Rubus Coreanus Miq. and Angelica gigas Nakai extracts in conbination with ultrasonification. The extract yields of plants were the highest in the extraction system of 60^{circ}C and 40 kHz of ultrasonification. The immune cell growth ratio of human immune B and T cells was increased compared to other fractions by the water fraction of the plants at 60^{circ}C and 40 kHz. The water fractions of the plants at 60^{circ}C and 40 kHz increased the specific secretion of IL-6 and TNF-{alpha} of human immune B and T cells compared to other fractions of the plants. The water fraction of Ehpedrae Sinica STAPF among the plants was observed to show the highest specific secretion of IL-6 and TNF-{alpha}. Also, NK-92 MI cells growth was increased in adding the water fractions of the plants at 60^{circ}C and 40 kHz. The water fraction of Ehpedrae Sinica STAPF among the plants showed the highest in NK-92 MI cell growth ratio. The differentiation activity of the HL-60 cells significantly increased in adding the water fraction of Ehpedrae Sinica STAPF compared to other fractions of the plants. These results suggest that the water fractions of the plants in extraction system of temperature 60^{circ}C and ultrasonification 40 kHz have marked useful immuno-stimulatory activities.
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KEYWORD
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Ehpedrae Sinica STAPF, Rubus Coreanus Miq. and Angelica gigas Nakai immune activity, cytokine, NK cell, HL-60
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